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Streptococcus mutansÀÇ ¿ì½Ä È°¼º¿¡ ¹ÌÄ¡´Â PropolisÀÇ È¿°ú

EFFECTS OF PROPOLIS TO THE CARIOGENIC ACTIVITY OF STREPTOCOCCUS MUTANS

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±è´ë¹ü/Dae Beom Kim ÁÖÈÆ/¹éº´ÁÖ/¼Û¿Ï¿±/¼Û¿äÇÑ/Hoon Ju/Byeong Ju Baik/Wan Yeob Song/Yo Han Song

Abstract

°á·Ð
¿¡Åº¿Ã·Î ÃßÃâÇÑ propolis°¡ Ä¡¾Æ¿ì½Ä¿ø¼º¼¼±ÕÀÎ Streptococcus mutans JC-2(Ç÷ûÇü c), S.
mutans LM-7(Ç÷ûÇü e), ±×¸®°í S. mutans OMZ-175(Ç÷ûÇü f)ÀÇ ¼ºÀå°ú Ÿ¾×À¸·Î µµ¸»ÇÑ
hydroxyapatite ºñµå¿¡ÀÇ ºÎÂø¿¡ ¹ÌÄ¡´Â ¿µÇâ, ±×¸®°í glucosyltransferaseÀÇ È°¼º¿¡ ´ëÇÑ ¿µ
ÇâÀ» Á¶»çÇÑ °á°ú ´ÙÀ½°ú °°Àº °á°ú¸¦ ¾ò¾ú´Ù.
1. PropolisÀÇ S. mutans ±ÕÁÖµéÀÇ ¼ºÀå¿¡ ´ëÇÑ ÃÖ¼Ò ¼ºÀå¾ïÁ¦ ³óµµ´Â 1 §¢´ç 500-1000§¶
À̾ú´Ù.
2. Propolis¸¦ ¼¼±Õ¿¡ ÷°¡ÇÏ¿© hydroxyapatite ºñµå¿¡ ´ëÇÑ ºÎÂø½ÇÇèÀ» ½ÃÇàÇÑ °á°ú 1 §¢
´ç 200§¶ÀÇ propolis³óµµ¿¡¼­, S. mutans JC-2 ±ÕÁÖ´Â 76%, LM-7 ±ÕÁÖ´Â 96%±îÁö ºÎÂøÀ»
¾ïÁ¦½ÃÄ×´Ù. ¶ÇÇÑ ºñµå¸¦ Ÿ¾×À¸·Î µµ¸»½Ã propolis¸¦ ÷°¡ÇÏ¿´À» °æ¿ì¿¡´Â ºÎÂø¿¡ ¿µÇâÀ»
¹ÌÄ¡Áö ¸øÇÏ¿´´Ù.
3. PropolisÀÇ GTase È°¼º¿¡ ´ëÇÑ ¾ïÁ¦È¿°ú´Â 1 §¢´ç 1600§¶ÀÇ propolis ³óµµ¿¡¼­, ºñ¼ö¿ë
¼º ±×¸®°í ¼ö¿ë¼º glucanÀ» »ý¼ºÇÏ´Â GTase ¸ðµÎ¿¡ À־ 93-100% È°¼ºÀ» ¾ïÁ¦½ÃÄ×´Ù.
#ÃÊ·Ï#
Propolis, a natural resinous product collected by honey bees, is known to exhibit
various biological activities including anti-microbial, anti-inflammatory, and anti-tumor
activities. The present study was designed to investigate the effects of ethanol extracted
propolis(EEP) on the growth, glucosyltransferase(GTase) activity, and adherence to the
saliva-coated hydroxyapatite(S-HA) beads of Streptococcus mutans JC-2(serotype c), S.
mutans LM-7(serotype e), and S. mutans OMZ-175(serotype f) in vitro.
We found that the EEP had minimal inhibitory concentrations of 500-1000§¶/§¢ against
S. mutans strains when these strains were cultured for 48 hours, and inhibited both
water-insoluble and water-soluble glucan synthesizing GTase activities of S. mutans
strains to the 93-100% at the concentration of 1600 §¶/§¢, and also we found that the
EEP inhibited the adherence of S. mutans strains to S-HA beads to the 76-96% at the
concentrations of 200 §¶/§¢. These results indicate that EEP has anti-cariogenic activity
in vitro.

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